The physiochemical characteristics of Phragmites communis trin polysaccharides and in vitro anti-diabetic effects of their different fractions
= 0.679 mg/mL) and significantly enhanced glucose uptake and glycogen synthesis in insulin-resistant HepG2 cells, attributable to its uronic acid-enriched structure. These findings highlight PTP-2 as a promising multi-target agent for diabetes management, underscoring the structure-activity relationship of plant polysaccharides.
Authors
- Zhanjun Chen (ORCID: https://orcid.org/0000-0002-1153-1099)
- Ke Feng (ORCID: https://orcid.org/0000-0002-4659-6052)
- Kundian Che
- Baogang Zhou
- Wenzhong Hu
- Sarengaowa
- Ran Liu
- Jialin Yang
- Wei Gao
- Haoyuan Luo
Institutions
- Macau University of Science and Technology (MO)
- Jilin University (CN)
- Zhuhai Institute of Advanced Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3389/fphar.2026.1727657
- Primary Topic
- Polysaccharides and Plant Cell Walls
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province