Photocatalyzed Radical Cross-Coupling of Allylic Esters with <i>N</i> -Aryl Glycinates and Benzyl Amines for sp <sup>3</sup> C–C Bond Formation

) bond formation. The approach demonstrates remarkable substrate versatility and functional group compatibility, enabling late-stage derivatization of diverse natural products. The reaction also achieves enantioselective control through chiral auxiliaries, such as (-)-menthol, underscoring its synthetic potential.

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Publication Details

Journal
Organic Letters
Published
2026-04-01
DOI
https://doi.org/10.1021/acs.orglett.6c01024
Primary Topic
Radical Photochemical Reactions
Type
article
Field-Weighted Citation Impact
0.00

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article

Photocatalyzed Radical Cross-Coupling of Allylic Esters with N -Aryl Glycinates and Benzyl Amines for sp 3 C–C Bond Formation

Guoqin Xia, Pengli Zhang, Xudong Yuan, Haihui Huang
Organic Letters
Radical Photochemical Reactions
article

Photocatalyzed Radical Cross-Coupling of Allylic Esters with N -Aryl Glycinates and Benzyl Amines for sp 3 C–C Bond Formation

Guoqin Xia, Pengli Zhang, Xudong Yuan, Haihui Huang
article en

Abstract

) bond formation. The approach demonstrates remarkable substrate versatility and functional group compatibility, enabling late-stage derivatization of diverse natural products. The reaction also achieves enantioselective control through chiral auxiliaries, such as (-)-menthol, underscoring its synthetic potential.

Organic LettersVol. 28(14)
Guangzhou University of Chinese Medicine (CN), Nanjing University of Chinese Medicine (CN), Shanghai Institute of Materia Medica (CN), Drug Discovery Laboratory (Norway) (NO), University of Chinese Academy of Sciences (CN)
National Natural Science Foundation of China, Zhongshan Science and Technology Bureau
Openalex Percentile: Top 29%
Radical Photochemical Reactions
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Photocatalyzed Radical Cross-Coupling of Allylic Esters with <i>N</i> -Aryl Glycinates and Benzyl Amines for sp <sup>3</sup> C–C Bond Formation — Guoqin Xia, Pengli Zhang, et al. · Organic Letters (2026) | TGRS Research Map | TGRS