Photocatalyzed Radical Cross-Coupling of Allylic Esters with <i>N</i> -Aryl Glycinates and Benzyl Amines for sp <sup>3</sup> C–C Bond Formation
) bond formation. The approach demonstrates remarkable substrate versatility and functional group compatibility, enabling late-stage derivatization of diverse natural products. The reaction also achieves enantioselective control through chiral auxiliaries, such as (-)-menthol, underscoring its synthetic potential.
Authors
- Guoqin Xia (ORCID: https://orcid.org/0000-0001-7666-9550)
- Pengli Zhang (ORCID: https://orcid.org/0000-0002-8554-4343)
- Xudong Yuan (ORCID: https://orcid.org/0000-0002-8683-4297)
- Haihui Huang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Shanghai Institute of Materia Medica (CN)
- Drug Discovery Laboratory (Norway) (NO)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/acs.orglett.6c01024
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhongshan Science and Technology Bureau