Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophages
. We also show that AMGs' indirect impacts are synergistically and antagonistically coupled, providing systems-level insight into AMG perturbations and highlighting how nontrivial cascading effects shape host metabolism.
Authors
- Jordan Quenneville (ORCID: https://orcid.org/0009-0000-1498-6614)
- David D. Pollock (ORCID: https://orcid.org/0000-0002-7627-4214)
- Margaret S. Cheung (ORCID: https://orcid.org/0000-0001-9235-7661)
- Angad P. Mehta (ORCID: https://orcid.org/0000-0003-2585-8268)
- Jordan C. Rozum (ORCID: https://orcid.org/0000-0002-4356-9809)
- Connah Johnson (ORCID: https://orcid.org/0000-0002-4672-9628)
- D. H. Kim
- William Sineath
- Wei-Jun Qian
- Pavlo Bohutskyi
- James Evans
- Ruonan Wu
Institutions
- Utah State University (US)
- Pacific Northwest National Laboratory (US)
- University of Illinois Urbana-Champaign (US)
- University of Washington (US)
- Environmental Molecular Sciences Laboratory (US)
- Washington State University (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Science Advances
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1126/sciadv.aeb7646
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Energy
- Environmental Molecular Sciences Laboratory