Mapping the Intratumoral and Peritumoral Microenvironment: Multilayered Shell ADC Analysis and Its Association with Multiparametric Biomarkers in Invasive Breast Cancer

The segmentation-based and improved multilayered shell model effectively captures the distance-dependent biological gradient of the peritumoral microenvironment. The intratumoral-to-peritumoral ADC ratios within the immediate 2 mm zone may provide complementary information regarding imaging markers of tumor aggressiveness when interpreted alongside absolute measurements. These findings suggest a potential role for these parameters as complementary imaging markers in preoperative risk stratification within a multiparametric framework.