Association between vaccination status and neurodevelopmental outcomes in children with cerebral palsy

Background: The safety of vaccines and their impact on functional outcomes in children with cerebral palsy remain significant concerns for both parents and healthcare providers. These concerns have limited the full implementation of routine immunization schedules in this specific population. Objective: This study aimed to investigate the association between vaccination status and the development of motor and communication functions in children with cerebral palsy. The findings are intended to inform the development of targeted vaccination strategies. Methods: = 207). Based on vaccination status, they were further classified into a vaccinated group (received at least one dose) and an unvaccinated group. Functional abilities were assessed using established classification systems, including the Gross Motor Function Classification System (GMFCS) and the Communication Function Classification System (CFCS). Vaccination completion rates were calculated according to the 2021 Chinese National Immunization Program Schedule. Statistical analyses included the Mann-Whitney U test and Spearman correlation to compare groups and examine relationships between vaccination completion rates and functional scores. Results: < 0.05). Conclusion: For children with cerebral palsy, routine vaccination is not only safe but may also exert a positive regulatory effect on neurological development. We recommend reinforcing routine immunization in this population and optimizing vaccination strategies through ongoing dynamic follow-up.