The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gα <sub>i1/3</sub> to reduce depressive-like behaviors in mice

Authors

Shizhong Cai (ORCID: https://orcid.org/0000-0003-2435-0315)
J. Marshall
Jin-long Chai
Huan Liu (ORCID: https://orcid.org/0000-0002-0253-647X)
Zhi-qing Zhang
Cong Cao (ORCID: https://orcid.org/0000-0003-0824-3472)
Yi-hang Shen
Meiqing Zhang
C. J. Xu
Xin Shi

Institutions

Brown University (US)
Soochow University (CN)
Second Affiliated Hospital of Soochow University (CN)

Publication Details

Journal: Science Signaling
Published: 2026-03-31
DOI: https://doi.org/10.1126/scisignal.aec8898
Primary Topic: Ubiquitin and proteasome pathways
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Natural Science Foundation of China
China Postdoctoral Science Foundation
Government of Jiangsu Province

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article

The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gα _i1/3 to reduce depressive-like behaviors in mice

Shizhong Cai, J. Marshall, Jin-long Chai, Huan Liu et al.

Mar 31, 2026

Science Signaling

Ubiquitin and proteasome pathways

article

The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gα _i1/3 to reduce depressive-like behaviors in mice

Shizhong Cai, J. Marshall, Jin-long Chai, Huan Liu, Zhi-qing Zhang, Cong Cao, Yi-hang Shen, Meiqing Zhang, C. J. Xu, Xin Shi

March 31, 2026article en

Abstract

No abstract available for this paper.

Science SignalingVol. 19(931)

Brown University (US), Soochow University (CN), Second Affiliated Hospital of Soochow University (CN)

National Natural Science Foundation of China, China Postdoctoral Science Foundation, Government of Jiangsu Province

Good health and well-being

Openalex Percentile: Top 29%

Ubiquitin and proteasome pathways

DOI Source OpenAlex

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