Early fibrotic gene activation precedes structural remodeling in the heart of cardiac myosin binding protein-C knockout mice
The effect of cMyBP-C ablation in the cardiac sarcomere induces cell-signaling changes that precede significant overt fibrosis. These data indicate that early clinical screening may allow for treatment before irreversible, pathological remodeling of the heart takes place.
Authors
- Bertrand C.W. Tanner (ORCID: https://orcid.org/0000-0003-1711-8526)
- Kyrah L. Turner (ORCID: https://orcid.org/0000-0001-8653-1256)
- Taylor G. Christopherson
Institutions
- Washington State University (US)
Publication Details
- Journal
- Physiological Genomics
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1152/physiolgenomics.00226.2025
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- American Heart Association
- National Institutes of Health