Patched controls cell cycle and tissue architecture in <i>Caenorhabditis elegans</i> gonad
In this study, we demonstrate how two hedgehog signaling pathway receptors influence germ cell development and reproduction. We identified the roles of Patched receptors in regulating germ cell maintenance, a process that is likely dependent on cholesterol homeostasis. Our findings reveal that dietary cholesterol levels impact Patched-driven germ cell behavior and gonad structure, highlighting the critical role of Patched in germline development.
Authors
- Johanna K Farley (ORCID: https://orcid.org/0009-0006-8590-7112)
- Sandeep Gopal (ORCID: https://orcid.org/0000-0002-6706-6747)
- Aqilah Amran (ORCID: https://orcid.org/0000-0003-1821-1191)
- Fredrik Forsberg (ORCID: https://orcid.org/0000-0001-7395-3302)
Institutions
- Lund University (SE)
- Australian Regenerative Medicine Institute (AU)
- Monash University (AU)
Publication Details
- Journal
- American Journal of Physiology-Cell Physiology
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1152/ajpcell.00486.2025
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancerfonden
- Crafoordska Stiftelsen
- Vetenskapsrådet
- Kungliga Fysiografiska Sällskapet i Lund
- Franke och Margareta Bergqvists Stiftelse för Främjande av Cancerforskning
- Stiftelsen Konsul Thure Carlssons Minne