Composition of Health Care Contact Days and Mortality Prediction Among Older Adult Clinical Trial Participants

PURPOSE: Contact days exceeding trial protocol-mandated care may represent adverse clinical events and portend worse outcomes. Identifying patients at risk of poor outcomes could enable clinical teams to intervene early and support patients' needs. MATERIALS AND METHODS: unplanned inpatient). Cox frailty landmark regression analysis was used in a random 60% training set to identify the optimal threshold (percentile) and landmark (months) for contact-day measures as the predictor based on the chi-square statistic. Candidate predictors were tested in the remaining 40% sample. RESULTS: = .014). CONCLUSION: One in five trial follow-up days was a health care contact day, of which the majority were unplanned ambulatory contact days. Meaningfully decreasing contact-day burdens will require addressing uncoordinated unplanned ambulatory contact days. The low threshold (≥1 in the first 2 months) of unplanned inpatient days in predicting mortality highlights the adverse impact of any acute care use on survival.

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Publication Details

Journal
JCO Oncology Practice
Published
2026-04-01
DOI
https://doi.org/10.1200/op-25-01182
Primary Topic
Frailty in Older Adults
Type
article
Field-Weighted Citation Impact
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article

Composition of Health Care Contact Days and Mortality Prediction Among Older Adult Clinical Trial Participants

Cathee Till, Michael LeBlanc, Joseph M. Unger, Arjun Gupta et al.
JCO Oncology Practice
Frailty in Older Adults
article

Composition of Health Care Contact Days and Mortality Prediction Among Older Adult Clinical Trial Participants

Cathee Till, Michael LeBlanc, Joseph M. Unger, Arjun Gupta, D. L. Hershman
article en

Abstract

PURPOSE: Contact days exceeding trial protocol-mandated care may represent adverse clinical events and portend worse outcomes. Identifying patients at risk of poor outcomes could enable clinical teams to intervene early and support patients' needs. MATERIALS AND METHODS: unplanned inpatient). Cox frailty landmark regression analysis was used in a random 60% training set to identify the optimal threshold (percentile) and landmark (months) for contact-day measures as the predictor based on the chi-square statistic. Candidate predictors were tested in the remaining 40% sample. RESULTS: = .014). CONCLUSION: One in five trial follow-up days was a health care contact day, of which the majority were unplanned ambulatory contact days. Meaningfully decreasing contact-day burdens will require addressing uncoordinated unplanned ambulatory contact days. The low threshold (≥1 in the first 2 months) of unplanned inpatient days in predicting mortality highlights the adverse impact of any acute care use on survival.

JCO Oncology Practice
Fred Hutch Cancer Center (US), City of Hope (US), Columbia University (US)
Good health and well-being
Openalex Percentile: Top 29%
Frailty in Older Adults
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