Developing a programme theory of a complex, home-based rehabilitation intervention for recovery after an episode of delirium
BACKGROUND: Delirium in older adults is associated with persistent cognitive and functional decline, increased institutionalisation, and higher mortality. Evidence-based strategies to support recovery after hospitalisation remain limited. This paper outlines the development and refinement of the programme theory underpinning RecoverED, a novel, home-based, multicomponent rehabilitation intervention designed to support post-delirium recovery. METHODS: We applied a realist-informed, multi-stage process to develop the RecoverED programme theory. This included a rapid realist review, qualitative interviews with older adults, carers, and healthcare professionals, an expert panel workshop, iterative programme theory meetings, and a process evaluation embedded within a single-arm feasibility trial. Data were synthesised into a logic model linking intervention components to hypothesised mechanisms and outcomes. RESULTS: The programme theory outlines how cognitive and physical rehabilitation, psychosocial support, health monitoring, lifestyle guidance, and delirium education are expected to promote recovery. Cognitive activities aim to rebuild executive function and daily independence; physical rehabilitation maintains mobility; psychosocial support reduces anxiety and promotes confidence; health monitoring and lifestyle guidance address comorbidities; and delirium education supports sense-making. Key mechanisms include personalised goal-setting, continuity of professional support, and integration with community services. The process evaluation within the feasibility trial confirmed the relevance and acceptability of these pathways, while suggesting refinements to training, psychosocial strategies, and education delivery. CONCLUSION: This paper provides an empirically grounded framework detailing the development and refinement of a programme theory for post-delirium rehabilitation, illustrating the value of flexible, theory-driven approaches to guiding recovery.
Authors
- Sarah Joanna Richardson (ORCID: https://orcid.org/0000-0002-5771-1845)
- Victoria A Goodwin (ORCID: https://orcid.org/0000-0003-3860-9607)
- Louise Allan (ORCID: https://orcid.org/0000-0002-8912-4901)
- Shruti Raghuraman (ORCID: https://orcid.org/0000-0002-7366-1147)
- Ellen H. Richards (ORCID: https://orcid.org/0000-0002-0899-5300)
- Rowan Harwood (ORCID: https://orcid.org/0000-0002-4920-6718)
- Annie Hawton (ORCID: https://orcid.org/0000-0002-1336-5899)
- Obioha Chukwunyere Ukoumunne (ORCID: https://orcid.org/0000-0002-0551-9157)
- Elizabeth Goodwin (ORCID: https://orcid.org/0000-0003-1351-9170)
- Linda Clare (ORCID: https://orcid.org/0000-0003-3989-5318)
- Alison Bingham (ORCID: https://orcid.org/0009-0004-3305-8724)
- Roberta Anderson
- Aseel Mahmoud
- Sarah Morgan-Trimmer
- Jinpil Um
Institutions
- University of Nottingham (GB)
- University of Exeter (GB)
- Cumbria Northumberland Tyne and Wear NHS Foundation Trust (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- NIHR Newcastle Biomedical Research Centre (GB)
- Queen's Medical Centre (GB)
- University of Southampton (GB)
- Peninsula College of Medicine and Dentistry (GB)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1371/journal.pone.0342149
- Citations
- 1
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 20.93
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Exeter
- National Institute for Health Research Applied Research Collaboration South West Peninsula
- Programme Grants for Applied Research
- NIHR Newcastle Biomedical Research Centre