Photoexcited Nitroarenes: A Workhorse for Strategic Synthesis of <i>N</i> -Heterocycles via Reductive C–N Coupling/Cyclization Cascade
-tethered nitroarenes at ambient temperature through a tandem C-N coupling/intramolecular cyclization. A nitrene intermediate is formed to furnish intermolecular C-N coupling with boronic acids, followed by intramolecular cyclization with pendant functional groups in a single operation. This metal-free, cascade annulation reaction is scalable and has been applied to the synthesis of APIs and drugs.
Authors
- Ranjan Jana (ORCID: https://orcid.org/0000-0002-5473-0258)
- Kangkan Pradhan (ORCID: https://orcid.org/0000-0002-7239-1229)
- Sourav Mandal
Institutions
- Indian Institute of Chemical Biology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/acs.orglett.6c00890
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Council of Scientific and Industrial Research, India
- University Grants Commission
- Science and Engineering Research Board