Identification of Blood Pressure‐Associated Metabolites by Integrating Metabolomic and Genetic Analysis
) may influence blood pressure regulation by modulating prostaglandin E3 levels. Mediation analysis indicated that l-glutamic acid statistically mediated 12.16-31.53% of the effect of lifestyle factors on blood pressure. These findings enhance our understanding of metabolic mechanisms underlying hypertension and highlight potential biomarkers and therapeutic targets for further investigation.
Authors
- Xiong‐Fei Pan (ORCID: https://orcid.org/0000-0002-9350-9230)
- Yuanjiao Liu
- Yimin Zhu
- Chunxiao Cheng
- Wei Shao
- Dan Zhou
Institutions
- Sichuan University (CN)
- Sir Run Run Shaw Hospital (CN)
- West China Hospital of Sichuan University (CN)
- Zhejiang Lab (CN)
- Zhoushan Hospital (CN)
- Central Hospital of Putuo District (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- MedComm
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/mco2.70718
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang University
- National Key Research and Development Program of China