Octopus sucker-inspired, Turkish gall extract-integrated microneedle patch for oral ulcer mitigation
and in rodents. Applied to oral ulcer lesions in rats, the microneedle system exhibited prolonged mucosal retention with sustained drug release, significantly accelerating epithelial regeneration. These findings establish the sucker-inspired herbal microneedle platform as a mechanochemically optimized therapeutic strategy and provide a translational framework for modernizing traditional herbal delivery.
Authors
- Xiaotan Dou
- Chuanhui Song (ORCID: https://orcid.org/0000-0002-3880-7868)
- Shilin Guo
- Cheng Zhao
- Lin Lin
- Wei Han
Institutions
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- iScience
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.isci.2026.115557
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Nanjing University
- Jiangsu Association for Science and Technology
- Nanjing Medical Science and Technique Development Foundation