Association between IL1B rs16944 polymorphism and the risk of idiopathic inflammatory myopathies

Introduction: rs16944 polymorphism and the risk of developing IIMs. Methods: rs16944 polymorphism was analyzed. Myositis-specific autoantibodies (MSAs), myositis-associated autoantibodies (MAAs), and antinuclear antibodies (ANAs) were determined. Results: = 0.0044, respectively). Also, a significant association could be observed with DM, polymyositis (PM), DM+PM, juvenile DM, amyopathic DM, antisynthetase syndrome (ASyS), and cancer-associated myositis (CAM). Enzyme levels of CPK presented significant differences in our IIMs patients. The rs16944 polymorphism is significantly associated with various clinicopathological characteristics. Conclusion: rs16944 CC (codominant and dominant models) and CCTT (overdominant) genotypes and the IIMs phenotype (OR = 4.6136, 3.4232, and 3.5387, respectively).