Mechanical activation of PIEZO1 drives AP-1–dependent PTGS2/PGE2 signaling and corneal inflammation
-AP-1-PTGS2/PGE2 axis as a core mechanotransduction pathway driving corneal inflammation. Given the widespread expression of PIEZO1, our results provide mechanistic insight into how abnormal mechanical forces trigger inflammatory responses, highlighting a potential framework for understanding mechano-inflammation across tissues.
Authors
- Jifeng Ren (ORCID: https://orcid.org/0000-0002-4315-2595)
- Yuqi Liu (ORCID: https://orcid.org/0000-0001-6021-0059)
- Haixia Zhang (ORCID: https://orcid.org/0000-0001-5489-5987)
- Yuqing Wang (ORCID: https://orcid.org/0009-0006-2028-8138)
- Xiuqing Qian
- Zongzheng Zou
- Shanshan Li
- Hui Tong
- Aojun Luo
- Ruiran Li
- Mengyuan Guo
Institutions
- Capital Medical University (CN)
- Beijing Automation Control Equipment Institute (CN)
Publication Details
- Journal
- iScience
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.isci.2026.115396
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China