Paraspeckles Are Associated with the Activation and Nuclear Localization of Unphosphorylated miR-34a
These data suggest that paraspeckles are associated with nuclear localization and early radiation-responsive activation of unphosphorylated miR-34a. This suggests a coordinated nuclear sequestration of this important miR in its unphosphorylated state to enable an enhanced radiation response.
Authors
- David W. Salzman
- Ihsan A. Turk
- Graham Read (ORCID: https://orcid.org/0000-0002-7716-6506)
- Whitaker Cohn (ORCID: https://orcid.org/0000-0001-9198-8904)
- Joanne B. Weidhaas (ORCID: https://orcid.org/0000-0002-5096-3281)
- Julian P. Whitelegge (ORCID: https://orcid.org/0000-0003-2763-7733)
- Emily Rietdorf (ORCID: https://orcid.org/0000-0003-3798-0922)
- Kristen M. McGreevy (ORCID: https://orcid.org/0000-0002-3767-5971)
- Cynthia Tsang (ORCID: https://orcid.org/0000-0001-9017-6269)
- Hanny Issawi
Institutions
- University of California, Los Angeles (US)
- Mira Dx (United States) (US)
- IONICS Mass Spectrometry (Canada) (CA)
Publication Details
- Journal
- Non-Coding RNA
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3390/ncrna12020012
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tobacco-Related Disease Research Program
- National Cancer Institute