Discovery of a chimeric transposase-transposon system for advanced genome engineering
system with regard to cell-specific productivity. These findings introduce a significant addition to the field of semi-targeted transgene integration technologies, offering substantial potential for enhancing biologics manufacturing.
Authors
- Robin Nilson (ORCID: https://orcid.org/0000-0002-2528-9547)
- Moritz J. Schmidt (ORCID: https://orcid.org/0000-0002-1933-1999)
- Franziska Reuss
- Benjamin Renner
- Daniel Heinzelmann (ORCID: https://orcid.org/0000-0001-5431-1398)
- Benjamin Lindner (ORCID: https://orcid.org/0000-0002-4609-3105)
- Nikolas Zeh (ORCID: https://orcid.org/0000-0003-4889-7761)
- Juergen Fieder
- Simon Fischer (ORCID: https://orcid.org/0000-0002-5188-7620)
- Patrick Schulz
- Emely Walker
Institutions
- Boehringer Ingelheim (Germany) (DE)
Publication Details
- Journal
- iScience
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.isci.2026.115548
- Primary Topic
- Chromosomal and Genetic Variations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Boehringer Ingelheim