Current surgical standards in the management of the axilla

Summary Axillary surgery in breast cancer has undergone a profound transformation in recent decades. While axillary lymph node dissection (ALND) was the unquestioned standard until the 1990s [1], associated morbidity including lymphedema rates as high as 25% in the affected arm [2], led to the widespread adoption of sentinel lymph node biopsy (SLNB). Recent data now suggest that even SLNB may be safely omitted in selected low-risk patients. This article reviews the evolution of axillary management, summarizes pivotal evidence from the INSEMA, SOUND and BOOG 13-08 trials, and discusses the clinical implications, limitations, and future directions of this ongoing de-escalation process.

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Publication Details

Journal
memo - Magazine of European Medical Oncology
Published
2026-04-01
DOI
https://doi.org/10.1007/s12254-026-01108-0
Primary Topic
Breast Cancer Treatment Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Current surgical standards in the management of the axilla

Florian Fitzal, Kerstin Wimmer
memo - Magazine of European Medical Oncology
Breast Cancer Treatment Studies
article

Current surgical standards in the management of the axilla

Florian Fitzal, Kerstin Wimmer
article en

Abstract

Summary Axillary surgery in breast cancer has undergone a profound transformation in recent decades. While axillary lymph node dissection (ALND) was the unquestioned standard until the 1990s [1], associated morbidity including lymphedema rates as high as 25% in the affected arm [2], led to the widespread adoption of sentinel lymph node biopsy (SLNB). Recent data now suggest that even SLNB may be safely omitted in selected low-risk patients. This article reviews the evolution of axillary management, summarizes pivotal evidence from the INSEMA, SOUND and BOOG 13-08 trials, and discusses the clinical implications, limitations, and future directions of this ongoing de-escalation process.

memo - Magazine of European Medical Oncology
Karolinska Institutet (SE), Hanusch Hospital (AT), Medical University of Vienna (AT)
Medizinische Universität Wien
Good health and well-being
Openalex Percentile: Top 28%
Breast Cancer Treatment Studies
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Current surgical standards in the management of the axilla — Florian Fitzal, Kerstin Wimmer · memo - Magazine of European Medical Oncology (2026) | TGRS Research Map | TGRS