Current surgical standards in the management of the axilla
Summary Axillary surgery in breast cancer has undergone a profound transformation in recent decades. While axillary lymph node dissection (ALND) was the unquestioned standard until the 1990s [1], associated morbidity including lymphedema rates as high as 25% in the affected arm [2], led to the widespread adoption of sentinel lymph node biopsy (SLNB). Recent data now suggest that even SLNB may be safely omitted in selected low-risk patients. This article reviews the evolution of axillary management, summarizes pivotal evidence from the INSEMA, SOUND and BOOG 13-08 trials, and discusses the clinical implications, limitations, and future directions of this ongoing de-escalation process.
Authors
- Florian Fitzal (ORCID: https://orcid.org/0000-0003-2617-3965)
- Kerstin Wimmer (ORCID: https://orcid.org/0000-0001-5484-6229)
Institutions
- Karolinska Institutet (SE)
- Hanusch Hospital (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- memo - Magazine of European Medical Oncology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1007/s12254-026-01108-0
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medizinische Universität Wien