PET/MRI with 89Zr-labelled antibodies provides insights into altered antibody pharmacokinetics in the chick embryo model
Zr-labelled antibodies in ovo revealed markedly altered pharmacokinetics in chick embryos, most likely due to the absence of FcRn. These findings indicate predominantly non-specific distribution and clearance of these radiolabelled antibodies in fertilised chicken eggs. This study underscores the importance of considering species-specific differences when interpreting in ovo data and the necessity of further research into the suitability of the in ovo model for evaluating different classes of radiotracers.
Authors
- Joachim Friske (ORCID: https://orcid.org/0000-0002-1830-8113)
- Daniel Gündel (ORCID: https://orcid.org/0000-0001-9743-2325)
- Markus Mitterhauser (ORCID: https://orcid.org/0000-0003-3173-5272)
- Theresa Balber (ORCID: https://orcid.org/0000-0002-8154-5680)
- Markus Kieler (ORCID: https://orcid.org/0000-0002-4082-5731)
- Marie Brandt (ORCID: https://orcid.org/0000-0001-8685-7352)
- Katarína Benčurová (ORCID: https://orcid.org/0000-0001-6762-0528)
- Thomas H. Helbich
- Marcus Hacker
- Klaus Kopka
- Cécile Philippe
Institutions
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.ejps.2026.107520
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00