Treatment of Mesenchymal Stem Cell-Derived Extracellular Vesicles with Extract of Cultured Lentinula edodes Modulates Breast Cancer Stem Cells and MicroRNA Reprogramming
. In vitro experiments showed inhibition of cancer stem cell proliferation after challenging the cells with AHCC-pretreated EVs. Conclusion: Our data demonstrated that AHCC may contribute to modulation of the tumor microenvironment, thus influencing the development of cancer stem cells.
Authors
- Farzaneh Sharifzad (ORCID: https://orcid.org/0000-0002-7959-4440)
- Chantal Matar (ORCID: https://orcid.org/0000-0003-0346-4751)
- Dylan Burger (ORCID: https://orcid.org/0000-0003-3951-2911)
- Roghayeh Shahbazi (ORCID: https://orcid.org/0000-0003-3586-3597)
- Nawal Alsadi (ORCID: https://orcid.org/0000-0001-7752-6658)
- Hamed Yasavoli-Sharahi
Institutions
- University of Ottawa (CA)
- Ottawa Hospital (CA)
Publication Details
- Journal
- Current Issues in Molecular Biology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3390/cimb48040368
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00