Tropism and Replication Competence of Cattle Influenza A(H5N1) Genotype B3.13 Virus in Human Bronchus and Lung Tissue
In 2024, influenza A(H5N1) genotype B3.13 viruses emerged from cattle and caused mild spillover infections in humans. Using human bronchus and lung tissue, we evaluated tropism, replication, and pathogenesis of 2 cattle influenza isolates. Those viruses showed moderate replication competence and induced robust proinflammatory responses, suggesting potential risk for human health.
Authors
- John M. Nicholls (ORCID: https://orcid.org/0000-0001-7217-7444)
- John CW Ho
- Ka‐Chun Ng (ORCID: https://orcid.org/0000-0001-7016-3209)
- Malik Peiris
- Michael C.W. Chan
- Kenrie P.Y. Hui
- Richard J. Webby
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3201/eid3205.251926
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00