TTN variants in pediatric cardiomyopathy: a retrospective cohort study

Background: variants and their associated cardiomyopathies and clinical outcomes. Methods: variants confirmed by whole-exome sequencing (WES) from January 2015 to December 2024. Univariable Cox regression analysis was conducted to identify independent risk factors for major adverse cardiovascular events (MACEs), and receiver operating characteristic analysis was used to determine its capability. In addition, the contribution of combined pathogenic variants with the TTN gene was assessed. Results: specifically in patients with dilated cardiomyopathy (DCM), with a higher prevalence of MACE occurrence. Conclusion: presented more severe adverse outcomes in DCM assessment.