Excited-State S <sub>N</sub> Ar Reactions of Nitroarenes
substitution, enabling reaction pathways that are inaccessible in the ground state. Following computational evaluation of common nucleophiles, we developed a synthetically practical protocol that enables denitrative substitution across diverse polycyclic arenes. These findings demonstrate that photoexcitation can reshape the aromatic character of arenes, thereby offering a new strategy to access previously inaccessible modes of arene functionalization.
Authors
- Gui‐Juan Cheng (ORCID: https://orcid.org/0000-0002-2818-2235)
- Zhen Lyu (ORCID: https://orcid.org/0000-0002-4795-2733)
- Tiantian Liang (ORCID: https://orcid.org/0000-0002-7680-2398)
- Fei Ye
Institutions
- Chinese University of Hong Kong (HK)
- Central China Normal University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/jacs.5c21841
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Basic and Applied Basic Research Foundation of Guangdong Province