Enhanced Immunotherapy for Glioblastoma Using a Cholesterol Oxidase-Loaded, Pd-Doped Cu <sub>3</sub> N Nanozyme-Based Multimodal Nanoplatform

PdN@CR significantly suppresses tumor growth and prolongs survival without systemic toxicity. Collectively, this study establishes a BBB-permeable, US-augmented nanoplatform as a promising ferroptosis/cuproptosis-based strategy for effective GBM therapy.

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Publication Details

Journal
ACS Nano
Published
2026-04-01
DOI
https://doi.org/10.1021/acsnano.6c00714
Primary Topic
Nanoplatforms for cancer theranostics
Type
article
Field-Weighted Citation Impact
0.00

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article

Enhanced Immunotherapy for Glioblastoma Using a Cholesterol Oxidase-Loaded, Pd-Doped Cu 3 N Nanozyme-Based Multimodal Nanoplatform

Songsong Xia, D Chen, G N Wang, Zi Zhu et al.
ACS Nano
Nanoplatforms for cancer theranostics
article

Enhanced Immunotherapy for Glioblastoma Using a Cholesterol Oxidase-Loaded, Pd-Doped Cu 3 N Nanozyme-Based Multimodal Nanoplatform

Songsong Xia, D Chen, G N Wang, Zi Zhu, Songyu Yang, Man Guo, Chenghao Yu, Lili Feng
article en

Abstract

PdN@CR significantly suppresses tumor growth and prolongs survival without systemic toxicity. Collectively, this study establishes a BBB-permeable, US-augmented nanoplatform as a promising ferroptosis/cuproptosis-based strategy for effective GBM therapy.

ACS NanoVol. 20(14)
Harbin Engineering University (CN), Harbin Medical University (CN), Second Affiliated Hospital of Harbin Medical University (CN)
National Natural Science Foundation of China, Natural Science Foundation of Hainan Province, Natural Science Foundation of Heilongjiang Province, Fundamental Research Funds for the Central Universities
Openalex Percentile: Top 30%
Nanoplatforms for cancer theranostics
DOISourceOpenAlex
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