Live and heat-treated Lactiplantibacillus plantarum induce distinct metabolic and immune responses in intestinal epithelial cells
-dependent manner, likely in response to alterations in bacterial surface components. Our findings demonstrate that bacterial viability influences host epithelial metabolic and immune responses, providing a mechanistic basis for the rational selection of probiotic or postbiotic strategies.
Authors
- Julio Villena (ORCID: https://orcid.org/0000-0003-4941-4960)
- Keita Nishiyama (ORCID: https://orcid.org/0000-0001-6483-0669)
- Yoshiya Imamura
- Nobuko Moritoki
- Hina Yoshida
- Fu Namai (ORCID: https://orcid.org/0000-0002-2939-4934)
- Leonardo Albarracín (ORCID: https://orcid.org/0000-0001-8216-2190)
- T. Hashimoto
- Tomoko Shindo
- Wakako IKEDA-OHTSUBO
- Kazuhiro Sonomura
- Yuta Takada
- Mikako Takahashi
- Junya Yamamoto
- Masatoshi Hori
- Kaho Matsumoto
- Haruki Kitazawa
- Yuji Tsujikawa
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Tohoku University (JP)
- Keio University (JP)
- Keio University Hospital (JP)
- Industrial Research Institute of Shizuoka Prefecture (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- Shimadzu (Japan) (JP)
Publication Details
- Journal
- iScience
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.isci.2026.115516
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uehara Memorial Foundation
- Japan Agency for Medical Research and Development
- Japan Racing Association
- Food Science Institute Foundation
- Japan Society for the Promotion of Science
- Bio-oriented Technology Research Advancement Institution