Concordance between different methods of detecting fungal-specific IgE antibody in asthma

. ImmunoCAP demonstrated the highest sensitivity and specificity; however, emerging systems, such as the GOLD chip and MeDALL microarray, showed promising improvements in multiplex capacity and detection limits. Meanwhile, several commercial assays have no publications documenting their diagnostic performance. Fungal sIgE detection remains heterogeneous. Newer microarray-based assays offer enhanced sensitivity and broader allergen profiling. Standardizing cutoff thresholds and incorporating recombinant fungal allergens are crucial for strengthening diagnostic precision and improving the clinical management of fungal asthma.