Elucidating the Multi-Target Anti-Pruritic Mechanism of Polygonatum odoratum via Integrated Network Pharmacology, Molecular Simulations, and GEO Dataset Validation
may exert anti-pruritic effects through the combined actions of inflammation suppression, skin barrier repair, and neural modulation, revealing a novel multi-target mechanism for pruritus therapy and potential synergy with levocetirizine.
Authors
- Chaoying Liu (ORCID: https://orcid.org/0000-0003-0484-9522)
- Jiabei Chen
- Guoliang Yu
- Xinbo Chen
- Zhen Li
Institutions
- Hunan Agricultural University (CN)
Publication Details
- Journal
- Current Issues in Molecular Biology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3390/cimb48040369
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00