Diagnostic Challenges in Severe Electrolyte Imbalance in Early Infancy: A Case Report of Secondary Pseudohypoaldosteronism

Secondary PHA should be considered in infants presenting with failure to thrive, dehydration, hyponatremia, and hyperkalemia, particularly in the presence of UTI or CAKUT. Early recognition and differentiation from primary adrenal disorders are essential to prevent life-threatening complications. Prompt correction of electrolyte imbalance and management of the underlying urinary tract pathology are crucial for favorable outcomes.

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Publication Details

Journal
Pediatric Reports
Published
2026-04-01
DOI
https://doi.org/10.3390/pediatric18020049
Primary Topic
Ion Transport and Channel Regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Diagnostic Challenges in Severe Electrolyte Imbalance in Early Infancy: A Case Report of Secondary Pseudohypoaldosteronism

Irina Halvadzhiyan, Stanimira Elkina, Venetsiya Bozhanova
Pediatric Reports
Ion Transport and Channel Regulation
article

Diagnostic Challenges in Severe Electrolyte Imbalance in Early Infancy: A Case Report of Secondary Pseudohypoaldosteronism

Irina Halvadzhiyan, Stanimira Elkina, Venetsiya Bozhanova
article en

Abstract

Secondary PHA should be considered in infants presenting with failure to thrive, dehydration, hyponatremia, and hyperkalemia, particularly in the presence of UTI or CAKUT. Early recognition and differentiation from primary adrenal disorders are essential to prevent life-threatening complications. Prompt correction of electrolyte imbalance and management of the underlying urinary tract pathology are crucial for favorable outcomes.

Pediatric ReportsVol. 18(2)
Medical University Pleven (BG)
Good health and well-being
Openalex Percentile: Top 35%
Ion Transport and Channel Regulation
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Diagnostic Challenges in Severe Electrolyte Imbalance in Early Infancy: A Case Report of Secondary Pseudohypoaldosteronism — Irina Halvadzhiyan, Stanimira Elkina, et al. · Pediatric Reports (2026) | TGRS Research Map | TGRS