<i>ATM</i> c.7374_7375insAlu is a French-Canadian founder pathogenic variant associated with predisposition to pancreatic and breast cancer
c.7374_7375insAlu as a novel FC founder PV that contributes to PC and BC predisposition. Improving carrier detection may identify at-risk relatives who may benefit from cancer-directed surveillance.
Authors
- Nancy Hamel
- Joan Miguel Romero (ORCID: https://orcid.org/0000-0002-4123-0051)
- Diane Provencher (ORCID: https://orcid.org/0000-0003-1902-3256)
- George Zogopoulos (ORCID: https://orcid.org/0000-0002-0482-7086)
- R. Lapointe
- Adeline Cuggia (ORCID: https://orcid.org/0000-0002-0316-0320)
- Céline Domecq
- Patricia N. Tonin
- Alejandro Mejia-Garcia
- William D Foulkes
- Anne-Marie Mes-Masson
- Simon Gravel
Institutions
- McGill University Health Centre (CA)
- McGill Genome Centre (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Journal of Medical Genetics
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1136/jmg-2025-111441
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- McGill University Health Centre
- Fondation de l'Hôpital Général de Montréal
- Partenariat Canadien Contre Le Cancer
- Health Canada
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé