Red Blood Cell Piezo1 Activation Drives Faster Coagulation and Structural Alterations in Blood Clots through Red Blood Cell Deformability Impairment
, and a reduction in RBC deformability. ROTEM analysis showed shorter clotting and lysis times in Yoda1-treated samples compared with samples treated with the vehicle (control condition), independently of RBC phosphatidylserine exposure. Electron microscopy revealed structural alterations in Yoda1-treated samples, with less compacted RBCs.Altogether, these findings indicate that Piezo1 activation disrupted RBC ion balance and membrane potential, leading to dehydration and decreased deformability. These alterations contributed to accelerated coagulation and compromised clot structure, suggesting a potential role of Piezo1 in modulating thrombotic risk in RBC-related disorders.
Authors
- Christophe Nougier (ORCID: https://orcid.org/0000-0003-0578-242X)
- Stéphane Égée (ORCID: https://orcid.org/0000-0002-6195-4639)
- Yesim G. Dargaud (ORCID: https://orcid.org/0000-0002-4888-1463)
- P. CONNES
- Marie Martin (ORCID: https://orcid.org/0000-0002-9904-5465)
- Hamdi Rezigue (ORCID: https://orcid.org/0009-0003-3765-3603)
- Lars Kaestner
- Anaelle de Wreede
- Elie Nader
- Bita Asghariastanehei
- Angelica Nino
- Philippe Joly
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Station Biologique de Roscoff (FR)
- Sorbonne Université (FR)
- Laboratory of Excellence GR-Ex (FR)
- Hospices Civils de Lyon (FR)
- Laboratoire Interuniversitaire de Biologie de la Motricité (FR)
- Saarland University (DE)
Publication Details
- Journal
- Seminars in Thrombosis and Hemostasis
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1055/a-2846-3643
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- H2020 Marie Skłodowska-Curie Actions