Towards Sustainable Bone Grafting: Life Cycle Assessment of Donor Cadaver-Derived Allograft (BMG) Production Using a BMP-Preserving Approach

BACKGROUND/OBJECTIVES: Healthcare activities contribute significantly to climate change and environmental pollution. The demand for bone grafting is increasing, and the biological properties of bone substitute materials are critically important. A methodology aimed at preserving BMPs may offer an opportunity to improve the biological properties of donor cadaver-derived bone grafts. The aim of this study was to conduct a life cycle assessment of the BMP-preserving approach used in allograft production in order to enhance the environmental sustainability of bone grafting. METHODS: Following primary data collection at the West Hungarian Regional Tissue Bank, environmental impacts were assessed using the OpenLCA software and the ReCiPe v1.03 (2016) midpoint and endpoint impact categories. A sensitivity analysis was also conducted under six alternative scenarios to evaluate which changes would have the greatest beneficial effect on environmental impacts. RESULTS: -eq. The environmental impacts of the production process also had a significant influence on human health, with a total DALY value of 6.58 h. The impacts were primarily driven by electricity consumption and the chemicals used; however, in several impact categories, waste management also contributed substantially. CONCLUSIONS: Transitioning to more sustainable energy sources (e.g., wind power) would substantially improve the environmental performance of allograft production. Further research is needed to identify more sustainable alternatives for the chemical agents used during processing.