151P Variables influencing biopsy adherence: Lessons from the cancer core europe (CCE) clinical trial basket of baskets

Results: Mic60 silencing led to significant upregulation of EMT-associated transcription factors, including Zeb2, Lbx1, Snail, Twist1, accompanied by increased Ncadherin and Vimentin expression and decreased E-cadherin levels.NF-B signaling was also activated upon Mic60 loss.In vivo, Mic60 depletion resulted in faster tumor growth and increased tumor weight, indicating a pronounced effect on tumor aggressiveness.Conclusions: These findings demonstrate that Mic60 loss drives a more aggressive breast cancer phenotype, characterized by activation of EMT-and NF-B-related pathways, increased migratory and invasive potential, and accelerated tumor growth in vivo.Mic60 loss thus acts as a key driver of BC aggressiveness and highlights Mic60-associated pathways as potential targets for prognostic and therapeutic strategies in aggressive BC.

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Publication Details

Journal
ESMO Open
Published
2026-04-01
DOI
https://doi.org/10.1016/j.esmoop.2026.106294
Primary Topic
Medication Adherence and Compliance
Type
article
Field-Weighted Citation Impact
0.00

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article

151P Variables influencing biopsy adherence: Lessons from the cancer core europe (CCE) clinical trial basket of baskets

Claudio Vernieri, RF Schlenk, Roberta Fasani, R.D. Baird et al.
ESMO Open
Medication Adherence and Compliance
article

151P Variables influencing biopsy adherence: Lessons from the cancer core europe (CCE) clinical trial basket of baskets

Claudio Vernieri, RF Schlenk, Roberta Fasani, R.D. Baird, Luigi De Petris, Elena Provenzano, C. Massard, Irene Braña, J-Y. Scoazec, J. Jimenez, M. Rotxes Costa, J. Carmona Sanz, J. Rodon Ahnert, A. Romero Tamarit, F. Opdam, E. Chavarria, G. Pruneri, F. Gallego, P.G. Nuciforo, M. Vlasov
article en

Abstract

Results: Mic60 silencing led to significant upregulation of EMT-associated transcription factors, including Zeb2, Lbx1, Snail, Twist1, accompanied by increased Ncadherin and Vimentin expression and decreased E-cadherin levels.NF-B signaling was also activated upon Mic60 loss.In vivo, Mic60 depletion resulted in faster tumor growth and increased tumor weight, indicating a pronounced effect on tumor aggressiveness.Conclusions: These findings demonstrate that Mic60 loss drives a more aggressive breast cancer phenotype, characterized by activation of EMT-and NF-B-related pathways, increased migratory and invasive potential, and accelerated tumor growth in vivo.Mic60 loss thus acts as a key driver of BC aggressiveness and highlights Mic60-associated pathways as potential targets for prognostic and therapeutic strategies in aggressive BC.

ESMO OpenVol. 11
The University of Texas MD Anderson Cancer Center (US), Institut Gustave Roussy (FR), Karolinska Institutet (SE), The Netherlands Cancer Institute (NL), Cancer Research UK Cambridge Center (GB), Vall d'Hebron Institut de Recerca (ES), National Center for Tumor Diseases (DE), Karolinska Development (Sweden) (SE), Vall d'Hebron Hospital Universitari (ES), CIBBIM-Nanomedicine (ES), Addenbrooke's Hospital (GB), Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Akershus Universitetssykehus, Eurostars
Zero hunger
Openalex Percentile: Top 36%
Medication Adherence and Compliance
DOIOpen Access PDFOpenAlex
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