The <i>Uppsala APP</i> Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo
accelerates aggregation and deposition of Aβwt species (Aβwt38, Aβwt40, Aβwt42), likely through a seeding or catalytic mechanism. Notably, bitransgenic mice developed pronounced plaque-associated gliosisan alteration absent in tg-UppSwe animals. These findings suggest a synergistic interaction betweenAβUpp and Aβwt that may influence onset, progression, and structural featuresof Aβ plaques in APPUpp mutation carriers.
Authors
- Enrica Cerilli
- Jörg Hanrieder (ORCID: https://orcid.org/0000-0001-6059-198X)
- Vilmantas Giedraitis (ORCID: https://orcid.org/0000-0003-3423-2021)
- María Pagnon de la Vega (ORCID: https://orcid.org/0000-0003-1845-9138)
- Ling Wu (ORCID: https://orcid.org/0000-0002-2072-1468)
- Greta Hultqvist (ORCID: https://orcid.org/0000-0002-4136-6792)
- Sertan Arkan (ORCID: https://orcid.org/0000-0003-2581-5620)
- Silvia Zampar (ORCID: https://orcid.org/0000-0003-0134-0974)
- Srinivas Koutarapu (ORCID: https://orcid.org/0000-0002-4355-6733)
- Junyue Ge (ORCID: https://orcid.org/0009-0005-9542-802X)
- Martin Ingelsson
- Lars Lannfelt
- Dag Sehlin
- Stina Syvänen
- Paul Fraser
Institutions
- Uppsala University (SE)
- University Health Network (CA)
- University of Toronto (CA)
- Sahlgrenska University Hospital (SE)
- Occupational Cancer Research Centre (CA)
- BioArctic Neuroscience (Sweden) (SE)
- National Hospital for Neurology and Neurosurgery (GB)
- Ontario Brain Institute (CA)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1002/advs.202514179
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stiftelsen för Gamla Tjänarinnor
- Hjärnfonden
- Vetenskapsrådet
- Alzheimerfonden
- National Institutes of Health