NDUFA5 deficiency promotes renal inflammation in diabetic nephropathy via mitochondrial ROS signaling

. Mechanistically, NDUFA5 attenuated inflammation by inhibiting mitochondrial reactive oxygen species (mtROS) generation. Thus, NDUFA5 protects against DN, at least in part, by preserving mitochondrial integrity and reducing oxidative stress and inflammation, highlighting its potential as a therapeutic target.

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Publication Details

Journal
iScience
Published
2026-04-01
DOI
https://doi.org/10.1016/j.isci.2026.115555
Primary Topic
Mitochondrial Function and Pathology
Type
article
Field-Weighted Citation Impact
0.00

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article

NDUFA5 deficiency promotes renal inflammation in diabetic nephropathy via mitochondrial ROS signaling

Li Mei MENG, Yunzhuo Ren, X. L. Wang, Guofang Gong et al.
iScience
Mitochondrial Function and Pathology
article

NDUFA5 deficiency promotes renal inflammation in diabetic nephropathy via mitochondrial ROS signaling

Li Mei MENG, Yunzhuo Ren, X. L. Wang, Guofang Gong, Xiuli Si
article en

Abstract

. Mechanistically, NDUFA5 attenuated inflammation by inhibiting mitochondrial reactive oxygen species (mtROS) generation. Thus, NDUFA5 protects against DN, at least in part, by preserving mitochondrial integrity and reducing oxidative stress and inflammation, highlighting its potential as a therapeutic target.

iScienceVol. 29(5)
Hebei Medical University (CN)
Natural Science Foundation of Hebei Province
Openalex Percentile: Top 37%
Mitochondrial Function and Pathology
DOIOpen Access PDFOpenAlex
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NDUFA5 deficiency promotes renal inflammation in diabetic nephropathy via mitochondrial ROS signaling — Li Mei MENG, Yunzhuo Ren, et al. · iScience (2026) | TGRS Research Map | TGRS