Systemic Dyslipidemia Drives Pan-Cancer Prognosis via Epigenetic Remodeling: A Hybrid Pi-Score Analysis

This study provides molecular evidence that systemic dyslipidemia, particularly elevated triglycerides, drives oncogenic epigenetic remodeling. The identification of CPT1A suggests that managing lipid profiles may be critical for mitigating the "metabolic fuel" that accelerates cancer progression. These findings advocate for integrating lipid biomarkers into cancer risk stratification.