Steady progress in the treatment of advanced prostate cancer: a year in review

PURPOSE OF REVIEW: This review is designed to highlight recent research efforts to optimize treatment strategies in men with advanced prostate cancer. RECENT FINDINGS: In hopes of improving outcomes in men with advanced prostate cancer, recent trials have focused on intensifying therapy earlier in the disease course both in men with biochemical recurrence and those with oligometastatic disease. Further research efforts have looked to refine the use of radiopharmaceuticals, targeted therapy, and combinations of existing agents. Finally, systemic therapies with novel targets may expand options for men with treatment-refractory metastatic castration-resistant disease. SUMMARY: Ongoing research focuses on maximizing the benefits of existing therapies while exploring treatments with new mechanisms of action.