Effectiveness of selective dorsal rhizotomy for spastic cerebral palsy: a systematic review and single-arm meta-analysis

INTRODUCTION: Selective dorsal rhizotomy (SDR) is used to treat spastic cerebral palsy (CP), but its effectiveness remains debated due to heterogeneous, predominantly non-randomized evidence. EVIDENCE ACQUISITION: statistic, and sensitivity analyses (including leave-one-out and varying correlation coefficients for missing SDs) were performed. EVIDENCE SYNTHESIS: =99%). Sensitivity analyses confirmed the stability of results across assumptions, and leave-one-out analyses did not materially alter effect estimates. All included studies were judged to have a moderate risk of bias. CONCLUSIONS: SDR is associated with clinically meaningful and durable improvements in gross motor function and reductions in spasticity in children with spastic CP.

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Publication Details

Journal
Journal of Neurosurgical Sciences
Published
2026-04-01
DOI
https://doi.org/10.23736/s0390-5616.26.06768-8
Primary Topic
Cerebral Palsy and Movement Disorders
Type
article
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article

Effectiveness of selective dorsal rhizotomy for spastic cerebral palsy: a systematic review and single-arm meta-analysis

João Paulo Teles, Vitor Expedito Alves Ribeiro, Filipe Virgílio Ribeiro, Hilária Saugo Faria et al.
Journal of Neurosurgical Sciences
Cerebral Palsy and Movement Disorders
article

Effectiveness of selective dorsal rhizotomy for spastic cerebral palsy: a systematic review and single-arm meta-analysis

João Paulo Teles, Vitor Expedito Alves Ribeiro, Filipe Virgílio Ribeiro, Hilária Saugo Faria, Maria Antonia Pereira, Victor Gonçalves Soares, João V. ANDRADE FERNANDES, Altair P. de MELO NETO, Gustavo S. NOLETO, Matheus S. FERREIRA, Helvécio N. FEITOSA FILHO, Izabely dos Reis de Paula
article en

Abstract

INTRODUCTION: Selective dorsal rhizotomy (SDR) is used to treat spastic cerebral palsy (CP), but its effectiveness remains debated due to heterogeneous, predominantly non-randomized evidence. EVIDENCE ACQUISITION: statistic, and sensitivity analyses (including leave-one-out and varying correlation coefficients for missing SDs) were performed. EVIDENCE SYNTHESIS: =99%). Sensitivity analyses confirmed the stability of results across assumptions, and leave-one-out analyses did not materially alter effect estimates. All included studies were judged to have a moderate risk of bias. CONCLUSIONS: SDR is associated with clinically meaningful and durable improvements in gross motor function and reductions in spasticity in children with spastic CP.

Journal of Neurosurgical Sciences
Universidade Federal da Paraíba (BR), Universidade de São Paulo (BR), Universidade do Estado do Pará (BR), Universidade Federal do Piauí (BR), Universidade Estadual do Piauí (BR), Universidade de Fortaleza (BR), Universidade Federal de Santa Maria (BR), Centro Universitário UNINOVAFAPI (BR), Centro Universitário Barão de Mauá (BR), Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR), Universidade Federal de Roraima (BR)
Openalex Percentile: Top 27%
Cerebral Palsy and Movement Disorders
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