Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation
I]4 due to rapid metabolism via radiodeiodination. Despite successful radiosynthesis and in vitro evaluation of iodine-123-labeled COX-2/5-LO inhibitors, improved inhibitory activity and stability are required for development of suitable radiotracers.
Authors
- Evamarie Hey‐Hawkins (ORCID: https://orcid.org/0000-0003-4267-0603)
- Robert Wodtke (ORCID: https://orcid.org/0000-0001-7462-7111)
- Sebastian Braun (ORCID: https://orcid.org/0000-0001-7693-318X)
- Maximilian Molitor (ORCID: https://orcid.org/0000-0002-1215-466X)
- Cathleen Haase‐Kohn (ORCID: https://orcid.org/0000-0002-5032-5095)
- Martin Ullrich (ORCID: https://orcid.org/0000-0001-6104-6676)
- Dieter Steinhilber (ORCID: https://orcid.org/0000-0001-8905-5208)
- Markus Laube (ORCID: https://orcid.org/0000-0003-4916-3794)
- Jens Pietzsch (ORCID: https://orcid.org/0000-0002-1610-1493)
- Jonas Schädlich (ORCID: https://orcid.org/0009-0002-4550-0394)
- Bettina Hofmann
- Klaus Kopka
Institutions
- Goethe University Frankfurt (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- Babeș-Bolyai University (RO)
- Technische Universität Dresden (DE)
- Leipzig University (DE)
Publication Details
- Journal
- ChemBioChem
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1002/cbic.202600004
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Deutsche Forschungsgemeinschaft