Non‐Classical <scp>HLA</scp> and <scp>MIC</scp> Risk Score Is Associated With Acute Kidney Transplant Rejection Beyond Classical <scp>HLA</scp> Matching

) and the replication cohort (HR 1.33, 1.10-1.62, p-value 0.004). The score added value beyond the standard HLA-A, -B, -DRB1 matching or HLA class I and II eplet matching, differentiating high and low-risk patient groups. The association remained when adding HLA-C and HLA-DQB1 matching to the analysis. The results demonstrate the value of considering the non-classical HLA and MIC genes in risk assessment and even graft allocation in kidney transplantation, and the potential of using oligogenic and polygenic summary scores to predict transplant outcomes.