<i>Syngap1</i> Synchronizes Relative Neuronal Maturation Across Cortical Areas to Organize Distributed Functional Networks
reduces this developmental separability through region-dependent, opposite-direction effects on dendritic maturation and inversion of ERK-sensitive control of intrinsic excitability. We propose that coordinated relative maturation of interacting neuronal populations establishes distributed network balance, and that gene-dependent shifts in this coordination produce stable, opposing network states.
Authors
- Thomas Vaissière (ORCID: https://orcid.org/0000-0001-9510-7510)
- Bianca Garcia-Gonzalez
- Randall M. Golovin (ORCID: https://orcid.org/0000-0003-1510-6126)
- Sheldon D. Michaelson
- Massimiliano Aceti (ORCID: https://orcid.org/0000-0002-6632-1398)
- Courtney A. Miller (ORCID: https://orcid.org/0000-0001-8628-4902)
- Gavin Rumbaugh (ORCID: https://orcid.org/0000-0001-6360-3894)
- Camilo Rojas (ORCID: https://orcid.org/0000-0003-2453-1730)
- Seth Butz
Institutions
- Scripps Research Institute (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-31
- DOI
- https://doi.org/10.64898/2026.03.27.714839
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 15.30