Distinct tissue niches contribute to prostate tissue-resident memory CD8+ T cell differentiation and heterogeneity
T cells were most persistent, cytotoxic, and enriched for the Trm molecular program. In sum, we provide a spatial framework for prostate Trm cell differentiation, charting the discrete tissue regions that influence T cell fate through dynamic regulation of localized signals.
Authors
- Maximilian Heeg (ORCID: https://orcid.org/0000-0002-9594-1377)
- Vida Luna (ORCID: https://orcid.org/0000-0002-6300-8128)
- Nicole E. Scharping (ORCID: https://orcid.org/0000-0001-9373-4617)
- Kennidy K. Takehara (ORCID: https://orcid.org/0000-0002-1990-155X)
- Matthew E. Pipkin (ORCID: https://orcid.org/0000-0002-9688-0190)
- Ananda W. Goldrath (ORCID: https://orcid.org/0000-0002-5900-508X)
- Amir Ferry (ORCID: https://orcid.org/0000-0003-2884-083X)
- K Mempel (ORCID: https://orcid.org/0009-0003-3825-9413)
- Peter J. Skene (ORCID: https://orcid.org/0000-0001-8965-5326)
- Sara Quon (ORCID: https://orcid.org/0000-0003-3860-3491)
- Kitty P. Cheung
- Giovanni Galletti (ORCID: https://orcid.org/0000-0001-6613-2354)
- Stephanie Añover-Sombke (ORCID: https://orcid.org/0000-0002-8530-8068)
- Violante Olivari (ORCID: https://orcid.org/0000-0002-1992-6706)
- Chinmayi Pandya (ORCID: https://orcid.org/0009-0001-7910-849X)
- John B. Johanneson (ORCID: https://orcid.org/0009-0002-7612-1290)
- J Ishibashi
- Peter P. Challita (ORCID: https://orcid.org/0009-0004-8634-031X)
- Nina Estep
- Natalie Zane
- Miguel Reina-Campos
- Ethan C. Xu
- Alexander Monell
- Rana R. McKay
- Baxter Melisso
Institutions
- Scripps Research Institute (US)
- La Jolla Institute for Immunology (US)
- University of California San Diego (US)
- Allen Institute for Immunology (US)
- La Jolla Institute For Molecular Medicine (US)
Publication Details
- Journal
- Immunity
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.immuni.2026.03.003
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases