Design and Synthesis of 9α-Hydroxyandrost-4-ene-3,17-dione Derivatives as Novel Potent Antiosteoporosis Agents

, SH494 markedly reduced ovariectomy-induced osteoclast activity and alleviated osteoporosis. Therefore, SH494 could serve as a promising lead for the development of novel antiosteoporotic agents.

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Publication Details

Journal
Journal of Medicinal Chemistry
Published
2026-03-31
DOI
https://doi.org/10.1021/acs.jmedchem.6c00008
Primary Topic
Bone Metabolism and Diseases
Type
article
Field-Weighted Citation Impact
0.00

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article

Design and Synthesis of 9α-Hydroxyandrost-4-ene-3,17-dione Derivatives as Novel Potent Antiosteoporosis Agents

Ruonan Ning, Jing-Zan Zhang, An-Qi Yu, Wen-Wei Qiu et al.
Journal of Medicinal Chemistry
Bone Metabolism and Diseases
article

Design and Synthesis of 9α-Hydroxyandrost-4-ene-3,17-dione Derivatives as Novel Potent Antiosteoporosis Agents

Ruonan Ning, Jing-Zan Zhang, An-Qi Yu, Wen-Wei Qiu, Yu-Xin Hu, Min Jiang
article en

Abstract

, SH494 markedly reduced ovariectomy-induced osteoclast activity and alleviated osteoporosis. Therefore, SH494 could serve as a promising lead for the development of novel antiosteoporotic agents.

Journal of Medicinal ChemistryVol. 69(7)
Ruijin Hospital (CN), East China Normal University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 30%
Bone Metabolism and Diseases
DOISourceOpenAlex
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