CRISPR Screens Reveal Epstein-Barr Virus-activated JunB as a Key Lymphoblastoid B cell Dependency Factor that Represses Cyclin Dependent Kinase Inhibitor P18INK4c
axis as essential for EBV- driven lymphoblastoid B cell proliferation, suggest JunB-mediated cross-talk between Epstein-Barr nuclear antigens and LMP1, and highlight JunB as a potential therapeutic target for EBV-associated lymphoproliferative disorders.
Authors
- Eric Burton (ORCID: https://orcid.org/0000-0002-2432-2288)
- Bidisha Mitra
- Davide Maestri
- Benjamin E. Gewurz (ORCID: https://orcid.org/0000-0002-3965-3418)
- Yifei Liao
Institutions
- Broad Institute (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-01
- DOI
- https://doi.org/10.64898/2026.03.31.715635
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Cancer Society
- National Institutes of Health