Variability of busulfan area under the concentration-time curve in children with different hematologic disorders

< 0.001). However, hematologic disorders was the only independent influencing factor of Bu AUC variation, after adjusting for the above variables.ConclusionVariability in Bu AUC was related to hematologic disorders of children with HSCT, which requires therapeutic drug monitoring and dose adjustment. Different phenotypes of patients should be considered when developing individualized Bu dosing regimen.