Trauma re-experiencing episodes during esketamine treatment in patients with treatment-resistant depression and comorbid PTSD: a retrospective case series
Our results suggest that esketamine can be safely administered to patients with comorbid PTSD and TRD, and that the occurrence of trauma re-experiencing episodes does not hinder clinical response.
Authors
- Raphaël Gaillard (ORCID: https://orcid.org/0000-0002-1297-4369)
- B. Gohier
- Aistė Lengvenytė (ORCID: https://orcid.org/0000-0001-9715-5145)
- Maud Rothärmel (ORCID: https://orcid.org/0000-0002-1947-0403)
- Lucie Berkovitch (ORCID: https://orcid.org/0000-0001-5098-7921)
- Andrew Laurin (ORCID: https://orcid.org/0000-0002-7806-961X)
- Raphaëlle Richieri
- Samuel Bulteau (ORCID: https://orcid.org/0000-0003-4855-2173)
- P Raynaud
- Macarena Cuenca
- François Kazour (ORCID: https://orcid.org/0000-0001-9337-4797)
- Virginie Moulier (ORCID: https://orcid.org/0000-0002-0402-0901)
- Pierre de Maricourt (ORCID: https://orcid.org/0000-0002-4776-3617)
- Eva-Maria Beetz-Lobono
- Thomas Husson (ORCID: https://orcid.org/0000-0002-4088-5021)
- Olivier Guillin
- Morgane Herrero
- A. Sauvaget
- L. Mekaoui
- Ludovic Samalin
- Wissam El-Hage
- Jérôme Holtzmann
- Emilie Olié
- David Szekely
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Yale University (US)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Imaging, Brain, and Neuropsychiatry (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- University of Clermont Auvergne (FR)
- NeuroSpine Institute (US)
- University of Fukui Hospital (JP)
- Centre Hospitalier Universitaire d'Angers (FR)
- Hôpital Nord (FR)
- Hôpital de Ville-Évrard (FR)
- Sigma Clermont (FR)
- Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale (FR)
- Institut Fresnel (FR)
- Centre Hospitalier du Rouvray (FR)
- Centrale Méditerranée (FR)
- FHU Neurovasc (FR)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- methodS in Patient-centered outcomes and HEalth ResEarch
- Nantes Université (FR)
Publication Details
- Journal
- European Journal of Psychotraumatology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1080/20008066.2025.2609425
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Philippe Foundation
- Fondation Bettencourt Schueller