Selective capture and digital counting of intact HIV pseudovirus using designer DNA nets, tethered motion, and photonic resonator interferometric scattering microscopy
virions/ml with a single-step, room temperature 30-min assay and excellent selectivity for non-detection of a nonspecific virus and the presence of a high concentration of extracellular vesicles. This study highlights PRISM's utility as a means for versatile detection of immobilized particles as part of an assay for affinity molecule evaluation.
Authors
- Joseph Tibbs (ORCID: https://orcid.org/0000-0002-6315-9778)
- Lijun Rong (ORCID: https://orcid.org/0000-0003-3938-0445)
- Colin L. Hisey (ORCID: https://orcid.org/0000-0001-8732-3600)
- Mengxi Zheng (ORCID: https://orcid.org/0000-0002-1625-6663)
- Skye Shepherd (ORCID: https://orcid.org/0000-0002-5684-7126)
- Saurabh Umrao (ORCID: https://orcid.org/0000-0002-9735-8062)
- Sydney Wiggins (ORCID: https://orcid.org/0009-0007-6039-8291)
- Katy Wolhaupter
- Tingjie Song
- Utkan Demirci
- Brian T. Cunningham
- Varada Anirudhan
- Xing Wang
Institutions
- Northwestern University (US)
- University of Illinois Urbana-Champaign (US)
- University of Illinois Chicago (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- APL Bioengineering
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1063/5.0289982
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institutes of Health
- University of Illinois at Urbana-Champaign