Computations Reveal How Firefly Luciferase Governs Side Reactivity of Superoxide
ion is essential for the final dioxetanone ring closure by charge neutralization, which reduces the electrostatic repulsion in the AMP cleavage step and prevents the formation of an adenylated dioxetanone analogue unproductive in light emission.
Authors
- Tatiana Domratcheva (ORCID: https://orcid.org/0000-0002-7001-1114)
- Anastasia R. Blinova
- Bella L. Grigorenko (ORCID: https://orcid.org/0000-0003-1372-4692)
Institutions
- Russian Academy of Sciences (RU)
- Lomonosov Moscow State University (RU)
- Institute of Biochemical Physics NM Emanuel (RU)
- Moscow State University (TJ)
Publication Details
- Journal
- Biochemistry
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/acs.biochem.6c00084
- Primary Topic
- bioluminescence and chemiluminescence research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation