Variation in corneal biomechanical properties following continuous cross-linking treatment

BACKGROUND: This retrospective study aimed to evaluate the efficacy of transepithelial accelerated corneal cross-linking (transEpi ACXL) when applied separately or combined with phototherapeutic keratectomy (transPTK ACXL) in keratoconic eyes using biomechanical parameters. METHODS: ), minimum and central corneal thickness (MCT and CCT), corneal coma, best-corrected visual acuity (BCVA), deformation amplitude ratio at 2 mm nasal/temporal (DAR2), integrated inverse radius (IIR), stiffness parameter at first applanation (SP-A1), highest concavity time (HCT) and two versions of stress-strain index (SSIv1 and SSIv2). RESULTS: , all P < 0.05). CONCLUSIONS: TransPTK ACXL resulted in better biomechanical and visual benefits in comparison with transEpi ACXL 6 months after treatment. SSIv2 demonstrated superior performance in assessing the efficacy of corneal cross-linking.

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Publication Details

Journal
Eye and Vision
Published
2026-04-01
DOI
https://doi.org/10.1186/s40662-026-00482-4
Primary Topic
Corneal surgery and disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Variation in corneal biomechanical properties following continuous cross-linking treatment

Xinyu Yao, Huijuan Wu, Yanjie Shen, Fangjun Bao et al.
Eye and Vision
Corneal surgery and disorders
article

Variation in corneal biomechanical properties following continuous cross-linking treatment

Xinyu Yao, Huijuan Wu, Yanjie Shen, Fangjun Bao, ShiHao Chen, Lei Yang, Chenhao Zhao, Yufeng Ye, Daniela Oehring, JiaHui Zong, YeWei Zhao, XiaoFei Zhou, XuanYa Tong, Jia Qu, Ying Li, Ahmed Elsheikh
article en

Abstract

BACKGROUND: This retrospective study aimed to evaluate the efficacy of transepithelial accelerated corneal cross-linking (transEpi ACXL) when applied separately or combined with phototherapeutic keratectomy (transPTK ACXL) in keratoconic eyes using biomechanical parameters. METHODS: ), minimum and central corneal thickness (MCT and CCT), corneal coma, best-corrected visual acuity (BCVA), deformation amplitude ratio at 2 mm nasal/temporal (DAR2), integrated inverse radius (IIR), stiffness parameter at first applanation (SP-A1), highest concavity time (HCT) and two versions of stress-strain index (SSIv1 and SSIv2). RESULTS: , all P < 0.05). CONCLUSIONS: TransPTK ACXL resulted in better biomechanical and visual benefits in comparison with transEpi ACXL 6 months after treatment. SSIv2 demonstrated superior performance in assessing the efficacy of corneal cross-linking.

Eye and VisionVol. 13(1)
Moorfields Eye Hospital NHS Foundation Trust (GB), University of Liverpool (GB), Shaoxing University (CN), Wenzhou Medical University (CN), National Institute for Health and Care Research (GB), Affiliated Eye Hospital of Wenzhou Medical College (CN), Zhejiang Lab (CN), Shaoxing People's Hospital (CN), University College London (GB), Zhejiang University (CN), University of Plymouth (GB)
National Natural Science Foundation of China, Medical Science and Technology Project of Zhejiang Province
Good health and well-being
Openalex Percentile: Top 37%
Corneal surgery and disorders
DOIOpen Access PDFOpenAlex
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