Generation of three hiPSC clones from a frontotemporal dementia (FTD) patient with a heterozygous MAPT mutation p.K298_H299insQ (c.896_897insACA)
A previously reported microtubule-associated protein tau (MAPT) mutation, p.K298_H299insQ, involving a glutamine insertion between lysine 298 and histidine 299, was identified in patients with frontotemporal dementia. We established induced pluripotent stem cell (iPSC) lines from a patient carrying this mutation. Generated iPSCs displayed typical pluripotency characteristics, differentiation potential into three germ layers, and stable karyotypes.
Authors
- Genko Oyama (ORCID: https://orcid.org/0000-0001-7985-5367)
- Y. Li
- Wado Akamatsu
- Taku Hatano
- Kei-ichi Ishikawa
- Takumi Hirose
- Nobutaka Hattori
Institutions
- RIKEN Center for Brain Science (JP)
- Juntendo University (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.scr.2026.103980
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 21.42
Funders
- Japan Agency for Medical Research and Development
- Promotion and Mutual Aid Corporation for Private Schools of Japan
- Japan Society for the Promotion of Science