A widespread gut bacterial lineage distinguished by redox metabolism and phage defense
Group B. This lineage was differentiated by its metabolic potential and bacteriophage defense, though mobile elements were shared broadly across the species. Notably, Group B was positively associated with intestinal inflammation in subjects with inflammatory bowel disease. Overall, these results emphasize the importance of bacterial population structure in host-microbiome interactions and provide a framework to study low-abundance gut taxa.
Authors
- Chhedi Lal Gupta (ORCID: https://orcid.org/0000-0001-9389-299X)
- Matthew H. Spitzer (ORCID: https://orcid.org/0000-0002-5291-3819)
- Than S. Kyaw (ORCID: https://orcid.org/0000-0002-7933-8615)
- Kai Trepka (ORCID: https://orcid.org/0000-0002-8672-6317)
- Joël Babdor (ORCID: https://orcid.org/0000-0002-1696-5814)
- Cecilia Noecker (ORCID: https://orcid.org/0000-0003-1417-2383)
- Peter J. Turnbaugh (ORCID: https://orcid.org/0000-0002-0888-2875)
- Lanjun Guo (ORCID: https://orcid.org/0000-0002-1175-6167)
- Luis A. Ramirez Hernandez
- Nitee Rai
- Fadima Daramy
- Cyrille Daté
- Connie W.Y. Ha
Institutions
- Minnesota State University, Mankato (US)
- University of California, San Francisco (US)
- Chan Zuckerberg Biohub San Francisco (US)
- Translational Therapeutics (United States) (US)
- UCSF Benioff Children's Hospital (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-01
- DOI
- https://doi.org/10.64898/2026.03.31.715625
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- U.S. Department of Defense
- University of Minnesota
- National Institutes of Health
- University of California, San Francisco
- Minnesota State University, Mankato